MOHAMED HUSSEIN
Egypt
Summary
My research focuses on: Exploring and enhancing the physicochemical, antimicrobial properties and biocompatibility of various kinds of nanoparticles, quantum dots, nanofibers and 3D bio-printed scaffolds for drug delivery, tissue regeneration and biomedical applications. Fabrication of novel nanoformulations composed of different components for biomedical applications. Incorporating hybrid nanoparticles/bioactive substances into hydrogel composite, electrospun nanofibers/ or 3D printed scaffolds for biomedical applications and other purposes. Photosensitizers-based nanoformulations for antimicrobial photodynamic inactivation Injectable thermoresponsive hydrogel nanocomposites
Overview
3
3
years of professional experience
2023
2023
years of post-secondary education
Work history
PhD
Faculty of Medicine, RWTH Aachen University – Germany
- During the PhD course I gained experience on designing, conducting, monitoring, and evaluating various functionalized nanoparticles. Such developed nanoparticles were incorporated into electrospun nanofibers as potential wound dressing mats using various electrospinning techniques such as monolayer electrospinning, coaxial electrospinning, layer-by-layer electrospinning and dual spinneret electrospinning techniques. The developed nanofibrous scaffolds were characterized morphologically, chemically, mechanically and their thermal stability were investigated. Drug release, antimicrobial properties and biocompatibility including MTT, fluorescence and SEM imaging were conducted.
- Projects: 2024/2026: PI of a Project 49179 provided by STDF-Egypt (2024) for 2 years, under the call of One Health Research and Innovation, which in the area of Photodynamic therapy against multidrug resistance pathogens: Studying the augmented antimicrobial photodynamic inactivation of nanoformulations against isolated resistant clinical pathogens
Researcher
Department of Pharmacology- Medical Research Institute– National Research Center (NRC), Egypt
2022.09 - 2026.01
- Mentor bench scientists to deliver high quality data to contribute to overall research goals.
- Collaborate with research groups to design novel formulations and components for various applications.
Education
PhD - Dr. rer. medic.
RWTH Aachen University
GermanyMaster of Pharmacology - undefined
Cairo University
EgyptBachelor of Veterinary Medicine - undefined
Assuit University
EgyptSkills
- Preparation and physicochemical characterization of various nanoplatforms including:
- Metallic and oxide nanoparticles
- Polymeric nanoparticles
- Mesoporous silica nanoparticles
- Cationic solid lipid nanoparticles for gene delivery (siRNA)
- Nanofibers
- 3D bio-printed scaffolds
- Thermoresponsive Hydrogel nanocomposites
- Quantum Dots
- Biological applications
- Formulation containing nano/components and characterization
- Drug Delivery of bioactive molecules via various nano-carrier systems
- Tissue regeneration (eg, wound healing, bone regeneration
- Antimicrobial activity, Anti-cancers, photodynamic therapy
- Catalytic nanomaterials for water decontamination and purification
- UV-VIS spectrophotometer
- Dynamic light scattering (DLS)
- Transmission Electron Microscope (TEM)
- Scanning Electron Microscope (SEM-EDX)
- Electrospinning
- 3D Bio-Printer
- Electrical conductivity
- Fourier Transform Infrared Spectra (FT-IR)
- X-Ray Diffraction (XRD)
- Differential Scanning Calorimetry (DSC)
- Thermo-gravimetric Analysis (TGA)
- Tensile measurements
- Rotatory evaporator, Lyophilizer
- Spray Drying
- EnVision Multilabel Plate Reader
- PDT
- GraphPad Prism & SPSS
- ImageJ
- MATLAB
- OriginPro
Projects
2024/2026: PI of a Project 49179 provided by STDF-Egypt (2024) for 2 years, under the call of One Health Research and Innovation, which in the area of Photodynamic therapy against multidrug resistance pathogens: Studying the augmented antimicrobial photodynamic inactivation of nanoformulations against isolated resistant clinical pathogens, 2025: A PI of a Project provided by Egyptian Academy of Sciences and technology, with a cooperation with Prof. Simo Schwartz, IP supervisor, Clinical Biochemistry, Drug Delivery and Therapy, Vall d’Hebron Research Institute, Autonomous University of Barcelona, Barcelona, Spain in a proposal entitled "Development of self-assembling short peptide-based injectable conductive supramolecular hydrogel composites for cardiac tissue engineering"., 2024/2027: Member in Project with Ref. 0024), entitled: Enhancement of microalgae higher-value products and developing microalgae-mediated nanomaterials., 2024/2027: Member in Project with Ref. 0097), and entitled: Design and developing nanonutraceuticals-based functional foods as promising therapeutic approaches for nutritional disorders., 2025/2028: Member in Project, entitled: Enhancing the anticancer performance of molecular targeted agents by developing multifunctional nanocarrier systems and photodynamic therapy
Reviewer Summary For manuscripts reviewed
- (4) Drug Development and Industrial Pharmacy
- (2) Advanced Healthcare Materials
- (1) Egyptian Journal of Chemistry
- (1) International Journal of Biomaterials
- (3) Carbohydrate Polymers
11 REVIEWS OF 7 MANUSCRIPTS For manuscripts published
- Targeting Peripheral Neurons: In-vitro characterization and In- vivo anti-nociceptive activity of tramadol hydrochloride encapsulated PEGylated albumin nanoparticles Reviewed: Jul 2024 for Drug Development and Industrial Pharmacy
- Potential Anticancer Effect of Free and Nanoformulated Deferasirov for Breast Cancer Treatment: In-vitro and In-vivo Evaluation Reviewed: Jan 2024 for Drug Development and Industrial Pharmacy
- Enhanced Anticancer Efficacy of Noscapine-Loaded Lipid Nanocapsules: In-vitro and In-vivo Evaluation Reviewed: Jan 2024 for Egyptian Journal of Chemistry
- Smart bactericidal capsules based on cationic luminescent nanoclusters for controllable treatment of drug-resistant bacterial infection 2 rounds from Nov 2023 to Dec 2023 for Advanced Healthcare Materials
- Multifunctional nanoparticles encapsulating methotrexate and curcumin for holistic management of rheumatoid arthritis: in-vitro and pre-clinical assessment 2 rounds from Jun 2023 to Jul 2023 for Drug Development and Industrial Pharmacy
- Electrospun methacrylamide chitosan-based nanofibers spatio-temporal releasing of drugs for accelerating wound repair, Jan 2023, Carbohydrate Polymers
- Hyaluronic acid / lactose-modified chitosan electrospun wound dressings – crosslinking and stability criticalities, Carbohydrate Polymers, July 2022
Timeline
Researcher
Department of Pharmacology- Medical Research Institute– National Research Center (NRC), Egypt
2022.09 - 2026.01
PhD
Faculty of Medicine, RWTH Aachen University – Germany
Master of Pharmacology - undefined
Cairo University
Bachelor of Veterinary Medicine - undefined
Assuit University
PhD - Dr. rer. medic.
RWTH Aachen University